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KMID : 0352419940130040368
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Keimyung Medical Journal
1994 Volume.13 No. 4 p.368 ~ p.373
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Increased Urine Fibronectin Concentrations in Diabetic Patients
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여준기
조정래/박정모/박근용/한승범/이인규/서성문/손건영/조준승
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Abstract
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Plasma fibronectin is an α2-glyoprotein, which is produced by vascular endothelial cells. Raised level of plasma fibronectin has been observed in diabetic patients particulary in the presence of microvascular complications. However, no available
data
exist about urine level of this glycoprotein in diabetic patients.
We measured urine fibronectin level by ELISA methods in 54 diabetic patients who have microvascular complications or not.
@ES The following results were obtained:
@EN 1) Urine fibronectin level(㎍/g creatinine) in diabetic group(1730.0±678.0) is increased compaired with those in normal control group(471.0±59.0). but this results were not significantly different among two groups(p>0.05).
2) Urine fibronectin level(㎍/g creatinine) was significantly increased in patients with nephropathy (6188.0±3144.0) compaired with those in normal control group(471.0±59.0) and patients without nephropathy(645.0±251.0)(P<0.001).
3) There were a significant correlation between BUN creatinine, creatinine clearance, 24hr urine total protein and urine fibronectin level in diabetic patients.
Our data suggest that urine fibronectin excretion level might be used as a sensitive guide for diabetic nephropathy.
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